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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

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Consequently, NRF2 activity increases, leading to the elevated expression of antioxidant enzymes such as glutathione S-transferase, NAD(P)H quinone oxidoreductase 1, and heme oxygenase-1 (260)

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Outside primary metabolic indications, these mechanisms are also of interest for cardiometabolic risk reduction (such as waist circumference, triglycerides, and blood pressure) and for appetite control during lifestyle-based weight loss plans