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Subsequently, the overexpression of the three candidate genes in respective plants was confirmed using quantitative Real-Time Polymerase Chain Reaction

What may appear as tolerance is often attributable to other factors such as dietary adaptation, metabolic compensation, or progression of underlying disease rather than true receptor-level tolerance to the medication itself

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This indicates that liraglutide might increase sensitivity to progesterone, suggesting that combining liraglutide with MPA could be a possible treatment for precancerous lesions and EC in the future [13]

Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects