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The body makes it in two steps

Numerous studies have also shown how important the portal glucose sensor is in maintaining glucose homeostasis and how GLP- 1 receptors are related to portal glucose sensing, with GLP- 1 being required for portal glucose to trigger the insulin response

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Various side effects have been reported with chronic IGF-1 therapy, including pain at the injection site and lipohypertrophy, headache, hypoglycemia, papilloedema, cataract, neoplasia, renal hypertrophy, and facial nerve palsy [80, 184]

Given that the gut produces the majority of the bodys serotonin and communicates directly with the brain via the vagus nerve, improvements in gut integrity naturally translate to improved neurological function