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Current reliance on preclinical evidence underscores the urgent need for rigorous clinical trials

Brutons tyrosine kinase and protein kinase C are required for TLR7/9-induced IKK and IRF-1 activation and interferon- production in conventional dendritic cells

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Kossoy, V

Data were analysed using a 3-parameter logistic fit in Prism and assessed for differences in fitted parameters from the parental construct at 95% confidence intervals