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Clinical Evidence: GLP-1 Therapy and Symptom Relief Beyond Weight Loss While no randomized trial has specifically studied semaglutide for hot flashes alone, observational data from weight loss clinics shows that women using GLP-1 medications report hot flash improvement at rates higher than can be explained by weight loss alone

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By regulating appetite and energy balance, GLP-1 therapies also support healthier circadian rhythms, enabling patients to achieve more restorative sleep

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