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General guidance: Keep a symptom diary noting when increased urination occurs, how much you are drinking, and any other symptoms
10.1056/NEJMoa2301972 36 JastreboffA
10.1007/s13402-018-0383-7 467 VandenbeekR.KhanN
we mean significant, sometimes dramatic shifts in efficacy and experimental clarity
Here's a real-world comparison of the weight loss data we have: Semaglutide 2.4 mg (Wegovy): ~15% body weight loss at 68 weeks in the STEP 1 trial Tirzepatide 15 mg (Zepbound): ~22.5% body weight loss at 72 weeks in SURMOUNT-1 Retatrutide 12 mg: ~24.2% body weight loss at 48 weeks in Phase 2 (shorter trial, remember) Promising, but still unproven at scale
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