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Observational studies can assess population-level outcomes but may miss granular data such as dose escalation, symptom burden, fasting quality, or anesthesia technique

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Pharmacognosy Rev

This gastrointestinal response typically peaks during the first 4-6 weeks and decreases significantly as tolerance develops, though proper dose timing and dietary choices play a major role in symptom severity

This review article aims at discussing the potential of therapeutic GLP-1 receptor agonists in alleviating depressive symptoms in the context of modern theories surrounding the pathogenesis of this disease and explores their influence on cognitive processes, neurotransmission, modulation of neuroinflammatory processes, effects on HPA axis activity, brain energy balance, and the functioning of the gut-brain axis