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Research shows that some people taking a PPI may benefit from magnesium supplementation if a deficiency is present, as confirmed by [a] physician. Meacham also emphasizes the importance of anyone with a known medical condition consulting their doctor before taking a dietary supplement

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Instead, CHAC1 expression is regulated by the oxidative stress response transcription factor NRF2

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doi:10.1038/s41598-018-28362-5