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second, the knockdown of SESN2 leads to a reduction in the translocation of p62 to the mitochondria and decreases its phosphorylation level at critical sites (such as Ser403), which is necessary for the encapsulation of the mitochondria by autophagosomes

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Flushing: A temporary feeling of warmth or redness in the face and neck right after the injection

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Intraduodenal injection and all blood sampling was performed in anaesthetized rats

For these individuals, medications such as Mounjaro or Wegovy may be more effective when used as part of a long-term management strategy rather than a defined short course