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We determined 505 probe sets (p.s.) representing CR mice DEGs, with 467 unique annotated gene symbols (Supplementary Data 1A-B)

Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats

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This dual action helps normalize blood glucose with lower risk of hypoglycemia compared to some older diabetes medications, though the risk increases when combined with insulin or sulfonylureas

For ongoing authorization renewals, periodic BMI documentation may be required to demonstrate continued medical necessity