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In laboratory models, DSIP is associated with modulation of the hypothalamicpituitaryadrenal axis and broader neurochemical signaling processes that govern circadian rhythm, hormonal release, and cellular stress adaptation

Infants of B12-deficient mothers can develop deficiency within the first two to three months of life, presenting with poor feeding, irritability, and developmental slowness

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Due to the risk of severe drug interactions and other serious adverse effects with ketoconazole oral tablets, ketoconazole oral tablets should not be a first-line treatment for any fungal infection in the geriatric patient

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Effects often noticed within days to weeks