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Immune activation in orthotopic osteosarcoma mouse model Cell experiments demonstrated that H 2 O 2 generated by NP4 could activate macrophages and mediate immune responses

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These safety assessments must unequivocally demonstrate that genetically modified organisms cannot persist in the environment, lack transferable antibiotic resistance markers, and are incapable of disseminating any deleterious genetic material to other microbiota (99)

Finally, we outline future directions within an ethnopharmacological perspective, integrating traditional knowledge with pharmacological innovation to inform multi target, standardized, and potentially personalized interventions for defined ASD endophenotypes

Later presentation and higher prevalence of chronic alcohol use disorder are likely contributing to the increased morbidity *

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