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By binding to ghrelin receptors in the hypothalamus, it mimics its functions, which are primarily reflected in the stimulation of appetite and the secretion of growth hormone

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Acylation with a fatty acid side chain enables albumin binding and a half-life of approximately 57 days, supporting once-weekly administration

For example, in a recent study, menopausal women with obesity or overweight lost more weight when tirzepatide was used along with HRT, and they had better cardiometabolic outcomes