Ogawa, Y., Kinoshita, M., Shimada, S., Kawamura, M., Zinc and skin disorders, Nutrients, vol.10 issue 2
[2] It is important to note that whilst fatigue and general malaise may improve relatively quickly, complete symptom resolution requires adequate time for the body to replenish B12 stores and repair affected tissues

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These include: Deep cracks and scales on dry skin Yellow or orange color to the palms or soles of the feet Reddening of the palms Flushing in the face Darker skin in the mouth, gums, or creases of the palms Reddish spots on the skin Swollen face Wounds that are slow to heal Certain Medications Marks on the skin that are caused by medications are referred to as drug-induced pigmentation
If you've been consistent with daily dosing, proper reconstitution, and refrigerated storage, and still see zero change at 16 weeks, the issue is likely absorption or individual receptor sensitivity rather than insufficient dose
doi: 10.1124/pr.115.011395 19 ArodaVR