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Because these two medications operate on different systems, some healthcare providers may prescribe them together off-label to help patients who have not seen sufficient results from one medication alone

Parkinsons disease and neurodegeneration: GABA-collapse hypothesis

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However, MT-II is not approved for any medical use in the UK and carries significant safety concerns

Tsutsumi, Y., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Terawaki, Y., Tanaka, T., Murase, K., Motonaga, R., Tanabe, M., Yanase, T., et al