Erythrocyte GSH increased by 30-35% at the 1,000 mg dose after 6 months (Richie et al., Eur J Nutr, 2015) [12]
doi:10.1016/S0140-6736(14)61682-2
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Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases
no reliance should therefore be placed on them
John Buse, Director of the Diabetes Care Center at the University of North Carolina and a principal investigator in GLP-1 outcomes trials, has noted in published commentary that "the antioxidant milieu in type 2 diabetes is genuinely impaired, but whether exogenous supplementation corrects the underlying defect or simply raises circulating levels without tissue impact remains unresolved." [9] That distinction shapes the practical advice: correcting a documented deficiency (measured low whole-blood glutathione in a patient with poorly controlled diabetes) is a different clinical decision from empirically adding glutathione to a well-controlled patient already benefiting from dulaglutide's own oxidative-stress effects