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Incorporating NET biomarkers into clinical protocols could enable patient stratification and guide targeted NET-modulating therapiessuch as PAD4 inhibitors, DNase, or antioxidantsin combination with standard-of-care interventions, ultimately improving metabolic and reproductive outcomes

2 Patient results pretreatment showed an elevated fibrinogen, CD62p, PAC-1, and platelet aggregation rates when compared to the controls, while NO was lower in this cohort when compared to controls

Int Rev Psychiatry, 2008

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These context-dependent effects of cellular processes, transcription factors, and metabolites are present in many aspects of biology, influenced by the concomitant expression of receptors, metabolic enzymes/pathways of each cell, molecular partners, and convergent or divergent signaling/ transcription factors activation

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