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130,230 Of note, the decrease in HDAC91 induces the elevation of the acetylation level of histone H3K27 in the PPAR promoter region, resulting in promoted adipogenesis

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Our results showed that HFD SAL mice express more ICAM-1 than ND SAL mice, and semaglutide treatment prevented the HFD-induced ICAM-1 expression in the brain microvessels, indicating that HFD induces an inflammatory environment that affects the integrity of the bloodbrain barrier [32, 33]