In addition, tumor-associated intrinsic pathways such as MAPK/PI3K , WNT/-catenin , and PD-1 are closely associated with tumor angiogenesis, and interactions among these pathways affect DC maturation, and T-cell recruitment and activation, and subsequently promote drug resistance in breast cancer
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thaliana seedlings co-cultivated with the root-colonizing endophytic fungus Piriformospora indica suggesting an important role of the enzyme in the maintenance of mutualistic plant- fungal interaction (Vadassery et al., 2009)