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Beta-cell insufficiency though is a general driver in the process of relentless deterioration of insulin response, is influenced by other factors with agency in insulin sensitivity, namely lipoglucotoxicity associated with obesity to confirm a vicious circle.
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DOI: 10.1186/s12967-016-0985-7 [Google Scholar] Derynck R, Zhang YE
Stimulation of GLP-1Rs leads to cAMP elevation and subsequently activates PKA- and/or Epac-dependent signaling pathway
