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Gastrointestinal Burden GLP-1 receptor agonists slow gastric emptying and directly act on the GI tract which is why nausea, vomiting, constipation, and diarrhoea are among the most commonly reported side effects, especially during dose escalation

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J Membr Biol 89:18 Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N (1992) Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat

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