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Oral peptide drug delivery is limited by low permeability of the gastrointestinal tract and rapid enzymatic and pH-induced degradation in the stomach

10.3390/ijms222111444 302 MimaA

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In vivo dosing of liraglutide in animals, followed by gene expression analysis of the hypothalamus, documented an increase in CART, but not POMC, mRNA and the inhibition of increases in neuropeptide Y/agouti-related peptide

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That selectivity exists because Ipamorelin does not activate melanocortin-2 receptor (MC2R) or other off-target GPCRs that drive ACTH and prolactin release