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What should I do if I have severe gastrointestinal side effects from GLP-1 medications

Whilst these symptoms often improve with time, many women seek complementary approaches to support digestive comfort during treatment

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism editorial team

A 2015 paper in Nature Scientific Reports identified that gut microbiota actually convert berberine into dihydroberberine (DHB) in the intestinal wall, and it's the DHB that gets absorbed and then converts back to berberine in the bloodstream