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Cagrilintide is chemically complex same fatty-acid conjugation chemistry as semaglutide so synthesis shortcuts produce ineffective product, not just lower-potency product

doi:10.1002/ana.10483 2

suggest that this effect was mediated by the ability of GLP-1 to suppress platelet-derived growth factor (PDGF)-induced proliferation of vascular smooth muscle cells

The drugs can have unsavory side effects, most frequently nausea

Consider lowering the dose of these agents when coadministered with BYDUREON BCise Acute Kidney Injury May induce nausea and vomiting with transient hypovolemia and may worsen renal function