Mass spectrometry analyses The purified PGRMC1 (a.a.44195) proteins, the wild-type (apo and haem) and the C129S mutant (apo and haem), which included additional amino acid residues (GPLGSEF), were buffer-exchanged into 100 mmol l 1 ammonium acetate, pH 7.5, by passing the proteins through a Bio-Spin 6 column (Bio-Rad)
Lancet (2018) 391(10140):260718
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Your fatigue is severe, or it's lasting longer than several weeks instead of easing It comes with dizziness, fainting, a racing heart, chest pain, or shortness of breath You're unable to keep down food or fluids, or you have signs of dehydration Something just feels off to you you know your body better than anyone Persistent tiredness is worth mentioning even if it seems minor
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Mol Nutr Food Res 57:114125 Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A (2001) The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation
