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Serum testosterone, follicle stimulating hormone, luteinizing hormone, estradiol and prolactin were determined by enzyme-linked immunosorbent assays (ELISA)

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MiR-25 is overexpressed in both keratinocytes and melanocytes in response to oxidative stress, which decreases the activity of antioxidant enzymes and impairs melanosome transport, leading to redox imbalance [51]