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Recent work from our group demonstrated that the endogenous agonist for GLP-1R, GLP-1 (7-36), activates members from all G protein families at the plasma membrane 5

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This hormone responds to food intake and plays a critical role in regulating blood sugar levels by stimulating insulin secretion and reducing the production of glucagon, another hormone that raises blood sugar

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Additional benefits, such as modest weight loss and cardiovascular risk reduction, are considered valuable but historically secondary