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The esca disease is a devastating, but still poorly understood fungal disease of grapevine trunks

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It produces a slow, diffused degradation of immune regulation that becomes visible only years or decades later when it manifests as a diagnosable condition

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Supporting this, several studies have demonstrated upregulation of germ cell-specific genes and enhanced sperm parameters following PRP treatment [36, 64,65,66,67,68], further validating its potential to promote spermatogenesis