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10.1016/S0028-3908(01)00171-X Neuropharmacology 31 HoT

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Bloating is an early symptom of gastroparesis and ileus

Hypokalemia [see Warnings and Precautions (5.6)]

While no human cases have been confirmed in clinical trials, the FDA maintains this warning due to the theoretical mechanism and animal data, even though the relevance to humans remains uncertain

At higher doses, tirzepatides side effects can be more pronounced, which makes sense, since the dose ceiling is higher and you need those higher doses to achieve the stronger results