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Semaglutide Slows Epigenetic Aging in People with HIV-associated Lipohypertrophy Summary Snapshot Study Type: Double-blind, placebo-controlled randomized controlled trial (post-hoc epigenetic analysis) Sample Size: 108 participants (84 with paired epigenetic data: 45 semaglutide, 39 placebo) Duration: 32 weeks Primary Endpoint: Change in epigenetic age acceleration (EAA) across DNA methylation clocks The DNA Methylation Edge DNA methylation enabled sensitive, system-level detection of aging changes that traditional clinical endpoints would miss

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But theres a critical result the headlines largely skipped: The apitegromab group was not measurably stronger