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BTBR T+tf/J (BTBR) inbred mouse strain is the clinically most relevant model for the study of ASD, as the animal model exhibits all core characteristics of the disease

Skin purging can be caused by using a chemical exfoliant, which loosens any dirt or grime in the pore and speeds up cell turnover, bringing the clog in the pore to the surface faster

It is also needed for the liver to convert T4 into the active T3 form of thyroid hormone, which all the cells in the body need to function properly

In some embodiments, the otic formulation or composition comprises about 0.6% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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