Most patients see significant weight loss, better blood sugar, and improved cardiovascular markers the last of which appears to be somewhat independent of the weight loss itself
The most common side effects are gastrointestinal nausea, constipation, diarrhea, and bloating particularly during the first 4 to 8 weeks when doses are being increased
For oral contraceptive pills: Take your pill at a time of day when nausea is minimal (usually not within 2 hours of your Zepbound injection) If you vomit within 2 hours of taking the pill, treat it as a missed dose (follow package instructions for missed pills) If GI side effects are persistent, consider switching to a non-oral method (patch, ring, IUD, implant, injection) For non-oral contraceptives (patch, ring, IUD, implant, injection): No interaction concern These methods don't rely on GI absorption For barrier methods: No interaction The FDA label for Zepbound states: "Tirzepatide causes a delay in gastric emptying and may impact the absorption of concomitantly administered oral medications." This is a general statement about all oral medications, not specific to contraceptives
Studies have shown no significant difference in the amount lost by people depending on which trial they are on
Frankel questioned the use of the weight-loss drug, especially without strong guidance from a doctor
While most people are aware of gastrointestinal problems linked to the drugs, such as acid reflux, nausea, burning and constipation, lesser-known side effects range from bothersome to bizarre
