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Cell culture studies typically use concentrations of 500 nM to achieve maximal TrkB activation, with the EC50 in the 200 to 500 pM range

Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging

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For example, a single-center, randomized, open-label, parallel-group trial investigated pharmacokinetic interactions of oral semaglutide with omeprazole in 54 healthy subjects [64]