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44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model

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ResultsDemographic and clinical characteristics The major demographic and clinical characteristics of the 147 chronic HCV infected patients studied [65 males and 82 females, mean age 44 12 years (range 19-74)] are presented in Table I