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The drug reduces hepatic glucose production, enhances glucose uptake in the peripheral tissues and increases insulin sensitivity 115

This approval followed the SURMOUNT clinical trial program, which demonstrated mean weight reductions of 15% to 21% depending on dose, significantly exceeding results seen with lifestyle intervention alone

The number of H-bonds formed between fusion proteins and the receptors at each step of the simulation was counted to ensure that the binding interaction was stable throughout the MD simulation

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Leist MH, Gluskin LE, Payne JA