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Forms of berberine (and a couple of branded extracts) Berberine generally comes in one of four forms: Pure berberine: the natural alkaloid form extracted from the parts of berberine-rich plants Berberine hydrochloride (HCl): the salt form created by combining berberine with hydrochloric acid improved water solubility and, therefore, better absorption in the body

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Additional population studies have expanded these findings

Biomed Pharmacother 156:113801