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CAR-T cells are genetically engineered to express a chimeric receptor composed of an antibody against a tumor antigen (such as CD19), a cytoplasmic domain of the zeta chain of the T-cell receptor, and a costimulator domain 42,43

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While the half-life of endogenous GLP-1 is only a few minutes, these drugs have various modifications to decrease metabolism and slow release into the blood stream

Prolonged NSAID use similarly interferes with repair processes