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While GLP-1 medications like compounded semaglutide (Ozempic and Wegovy) 1 and compounded tirzepatide (Zepbound and Mounjaro) assist in weight loss by reducing appetite and improving blood sugar regulation, your body isnt immune to the natural physiological processes that come with weight loss

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Further, a mouse study of AD found that treatment with a dual GLP-1R/GIPR agonist significantly reduced reactive astrogliosis relative to treatment with the single GLP-1R agonist liraglutide [80]

This led to further study into the potential weight loss benefits

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The development of GLP-/GIP dual agonists provides a more complete scheme for the treatment of metabolic diseases, but the safety of more dual agonists or multiple agonists in clinical trials is also worthy of attention