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This process engages a coordinated network of regulated cell death that extends beyond ferroptosis to include crosstalk with necroptosis and pyroptosis, while being critically modulated by ferritinophagy and the paradoxical role of defective mitophagy

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141,142 Therefore, TLRs are potential therapeutic targets to cure disc degeneration and reduce discogenic pain

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2021 Jun;17(3):999-1013