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As expected, the depletion of CSE (Extended Data Fig

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Recent studies have also shown that SAM can act as a therapeutic agent for treating depression, as an antidepressant in Parkinsons disease, and in endogenous and bipolar patients with depression and hypomanic symptoms (67)

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The search strategy used to interrogate the EMBASE database is provided in Supplementary Table 1

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This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)

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