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Furthermore, different from the ordered -helical ECL1 in inactive GLP-1R 33 and -hairpin in inactive GCGR 36 that cover the binding pocket and probably block peptide insertion, ECL1 of active GLP-2R, GLP-1R and GCGR simultaneously move outward and stand upwards in line with TM2 and TM3

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Generally speaking, the absorption efficiency after oral administration may be affected by the gastrointestinal environment, and different physiological states of the gastrointestinal tract may lead to differences in absorption rate and degree

These molecules help regulate metabolism, growth and the body's inflammation response