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This increased toxicity is ascribed to the loss or malfunction of ATP7B, which induces hepatic PrP expression, thereby enhancing endocytic copper uptake and contributing to hepatic copper overload and toxicity

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[DOI] [PMC free article] [PubMed] [Google Scholar] Conze D, Brenner C, Kruger CL

These conditions affect muscles such as the quadriceps, gastrocnemius (calf), and hamstrings, causing them to shorten and contract