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Acne Tretinoin has been proven in countless studies to be effective in reducing the total number of acne lesions in patients, thus leading to significant clinical improvement

The TCA precipitation was based on Cold Spring Harbor Protocols 46 , with some modifications

Rhodes et al., 2022

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Diabetologia 64 , 709716 (2021)

Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans