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Activation of adenosine A 1 receptors by astrocytic ATP-derived adenosine generally suppresses synaptic activity across multiple brain regions, including the hippocampus [332337], cortex [338], cerebellum [339], retina [340], amygdala [341], and nucleus accumbens [342]

& Hausser, M

N Engl J Med 2019;381:84151.ArticlePubMed 72

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Despite advancements in molecular typing and targeted therapies that have improved the prognosis of some subtypes, the mechanisms driving AML heterogeneity and its microenvironmental interactions remain poorly understood (215)

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