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A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

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Traditionally, in vitro studies of intestinal biology have relied on immortalized cell lines, which, while informative, often fall short in recapitulating the intricate cellular interactions and physiological processes observed in the human intestine (169, 170)