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Habitual use of areca nut and betel quid is strongly associated with the onset of oral potentially malignant disorders such as oral submucous fibrosis and plays a central role in the development of oral squamous cell carcinoma (36, 37)

Nicotine affects the brain by releasing dopamine, creating feelings of pleasure, and reinforcing the habit of using tobacco

But there are some notable differences, too

Retrieved 15 May 2026

Common side effects include: Increased heart rate and palpitations : Nicotine stimulates adrenaline release, which can make some individuals feel jittery or notice their heart pounding

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