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the strongest study design for establishing temporal precedence would include at least three time points (see Figure 16-1): a wave 1 in which ever smokers would be eliminated from the sample and e-cigarette use would be assessed as the primary exposure variable
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It confirms that the favourable impact of stopping smoking is already evident in the few years after cessation, and that laryngeal cancer risk is reduced by over 70% ten or more years after stopping smoking
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