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Rhonda Patrick, a biomedical scientist and founder of FoundMyFitness, emphasizes: "NAD+ levels can go up when we exercise or fast, but NAD+ precursors like NR and NMN boost them further, supporting energy production and cellular repair."[17] She notes that combining lifestyle with supplementation yields optimal results

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Cartilage and osteoarthritis models published research has explored AOD-9604 in articular cartilage and chondrocyte models, sometimes in combination with HA or other matrix peptides

A useful overview of that link is in microbiota-immune, which explains how microbes steer immune behavior