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However, it should be considered that fusion protein B7-H3-Ig and innate membrane B7-H3 are different, the same as TLT-2 expression in transfected cells and TLT-2 normally found on cells ( 3.2 Interleukin 20 receptor subunit alpha (IL20RA) Using new interactome technique, Husein et al

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Coupled with limited potency on MC3R and MC4R compared to other MC agonists, this explanation for the lack of MC4-NN20453 efficacy is plausible