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GLP-1 RAs have also been suggested to be nephroprotective [10], even though conflicting data on renal sodium and water handling have been reported [10,11,12]

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In addition, although overweight and obesity is markedly more common, some individuals with advanced HF like HFrEF are also cachexic (Rossignol et al., 2015) and may therefore not benefit from the weight-reducing effect of GLP-1 RAs

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